PIK-III

Overview
Catalog #	bs-6477c-10mg-solid
Product Name	PIK-III
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 319.36 Formula: C17 H17 N7 CAS Number: 1383716-40-2 InChi Key: XXSDLQLNIVFIJI-UHFFFAOYSA-N InChi: InChI=1S/C17H17N7/c18-16-21-10-13(15(23-16)9-11-1-2-11)14-5-8-20-17(24-14)22-12-3-6-19-7-4-12/h3-8,10-11H,1-2,9H2,(H2,18,21,23)(H,19,20,22,24) Smiles: NC1N=C(CC2CC2)C(=CN=1)C1C=CN=C(NC2C=CN=CC=2)N=1 Purity: 98.0 Solubility: Soluble in DMSO Appearance: Solid Power Shelf Life: 1.0 years
Description	PIK-III, also known as VPS34-IN2, is a VPS34 inhibitor which blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. PIK-III binds a unique hydrophobic pocket not present in related kinases such as PI(3)Kα. PIK-III acutely inhibits autophagy and de novo lipidation of LC3, and leads to the stabilization of autophagy substrates. .