ML224

Overview
Catalog #	bs-6466c-2mg-solid
Product Name	ML224
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 525.59 Formula: C31 H31 N3 O5 CAS Number: 1338824-21-7 InChi Key: BFTSWGYWHRJVNI-UHFFFAOYSA-N InChi: InChI=1S/C31H31N3O5/c1-19-14-24(32-21(3)35)15-20(2)29(19)39-18-23-16-22(11-12-28(23)37-4)30-33-27-10-6-5-9-26(27)31(36)34(30)17-25-8-7-13-38-25/h5-16,30,33H,17-18H2,1-4H3,(H,32,35) Smiles: COC1C=CC(=CC=1COC1=C(C)C=C(C=C1C)NC(C)=O)C1NC2=CC=CC=C2C(=O)N1CC1=CC=CO1 Purity: 98.0 Solubility: Soluble in DMSO Appearance: Solid Power Shelf Life: 1.0 years
Description	ML224, also known as NCGC00242364 and ANTAG3, is a selective TSHR inverse agonist; inhibits TSH-stimulated cAMP production with an IC50 = 2.3 μM. ML224 could be a useful tool for studying TSHR functions; it could also be a potential lead for development of drugs to treat TSHR-mediated hyperthyroidism caused by constitutively activating mutations or stimulating auto-antibodies associated with Graves’ disease.