ABT-888 dihydrochloride

Overview
Catalog #	bs-6445c-10mg-solid
Product Name	ABT-888 dihydrochloride
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 317.21 Formula: C13 H18 Cl2 N4 O CAS Number: 912445-05-7 InChi Key: DSBSVDCHFMEYBX-FFXKMJQXSA-N InChi: InChI=1S/C13H16N4O.2ClH/c1-13(6-3-7-15-13)12-16-9-5-2-4-8(11(14)18)10(9)17-12;;/h2,4-5,15H,3,6-7H2,1H3,(H2,14,18)(H,16,17);2*1H/t13-;;/m1../s1 Smiles: Cl.Cl.C[C@@]1(CCCN1)C1NC2C(=CC=CC=2N=1)C(N)=O Purity: 98.0 Solubility: Soluble in DMSO Appearance: Solid Power Shelf Life: 1.0 years
Description	ABT-888 dihydrochloride, also known asVeliparib, is a potent and selective Poly (ADP-Ribose) Polymerase (PARP) Inhibitor. ABT-888 dihydrochloride enhances apoptosis and autophagy in response to treatments that cause DNA breaks, including radiation and DNA alkylation. ABT-888 dihydrochloride is an orally bioavailable inhibitor of PARP1 and PARP2 (Kis = 5.2 and 2.9 nM, respectively).