PLX-647

Overview
Catalog #	bs-6408c-2mg-solid
Product Name	PLX-647
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 382.38 Formula: C21 H17 F3 N4 CAS Number: 873786-09-5 InChi Key: NODCQQSEMCESEC-UHFFFAOYSA-N InChi: InChI=1S/C21H17F3N4/c22-21(23,24)17-6-3-14(4-7-17)11-26-19-8-5-15(12-27-19)10-16-13-28-20-18(16)2-1-9-25-20/h1-9,12-13H,10-11H2,(H,25,28)(H,26,27) Smiles: FC(F)(F)C1=CC=C(CNC2C=CC(CC3=CNC4=NC=CC=C34)=CN=2)C=C1 Purity: 98.0 Solubility: Soluble in DMSO, not in water Appearance: Solid Power Shelf Life: 1.0 years
Description	PLX-647 is PLX647 is a potent inhibitors of both FMS and KIT that show strong selectivity compared with other kinases. In the in vitro enzymatic assay, PLX647 inhibits FMS with IC50 = 0.028μM and KIT with IC50 = 0.016 μM. PLX647 represents a unique class of kinase inhibitors with unique dual FMS and KIT specificity.