AC220

Overview
Catalog #	bs-60435c-2mg-solid
Product Name	AC220
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 633.59 Formula: C29 H34 Cl2 N6 O4 S CAS Number: 950769-58-1 InChi Key: DHYPGRVMIOATAE-UHFFFAOYSA-N InChi: InChI=1S/C29H32N6O4S.2ClH/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34;;/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36);2*1H Smiles: Cl.Cl.CC(C)(C)C1=CC(NC(=O)NC2C=CC(=CC=2)C2=CN3C(=N2)SC2C=C(C=CC3=2)OCCN2CCOCC2)=NO1 Purity: 98.0 Solubility: DMSO: ≥ 33 mg/mL Appearance: Solid Power Shelf Life: 1.0 years
Description	Quizartinib, also know as AC220 and AC010220, is an orally available FLT3 / STK1 inhibitor with potential antineoplastic activity. Class III receptor tyrosine kinase inhibitor AC220 selectively inhibits class III receptor tyrosine kinases, including FMS-related tyrosine kinase 3 (FLT3/STK1), colony-stimulating factor 1 receptor (CSF1R/FMS), stem cell factor receptor (SCFR/KIT), and platelet derived growth factor receptors (PDGFRs), resulting in inhibition of ligand-independent leukemic cell proliferation and apoptosis. Mutations in FLT3, resulting in constitutive activation, are the most frequent genetic alterations in acute myeloid leukemia (AML) and occur in approximately one-third of AML cases.