ADX47273

Overview
Catalog #	bs-60433c-2-mg-solid
Product Name	ADX47273
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 369.36 Formula: C20 H17 F2 N3 O2 CAS Number: 851881-60-2 InChi Key: VXQCCZHCFBHTTD-HNNXBMFYSA-N InChi: InChI=1S/C20H17F2N3O2/c21-16-7-3-13(4-8-16)18-23-19(27-24-18)15-2-1-11-25(12-15)20(26)14-5-9-17(22)10-6-14/h3-10,15H,1-2,11-12H2/t15-/m0/s1 Smiles: O=C(C1C=CC(F)=CC=1)N1C[C@H](CCC1)C1=NC(=NO1)C1C=CC(F)=CC=1 Purity: 98.0 Solubility: DMSO: ≥ 31 mg/mL Appearance: Solid Power Shelf Life: 1.0 years
Description	ADX-47273 is a potent and selective mGluR5 receptor PAM (positive allosteric modulator), EC50 = 0.17 μm, with no effect on other mGluR subtypes. In vivo, ADX47273 increased extracellular signal-regulated kinase and cAMP-responsive element-binding protein phosphorylation in hippocampus and prefrontal cortex, both of which are critical for glutamate-mediated signal transduction mechanisms. The mGluR (metabotropic glutamate receptor) is a group of G-protein coupled receptors and is active through an indirect metabotropic process. It plays a critical role in regulating synaptic plasticity and neural network activity.