AZD-1480

Overview
Catalog #	bs-60424c-2-mg-solid
Product Name	AZD-1480
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 348.77 Formula: C14 H14 Cl F N8 CAS Number: 935666-88-9 InChi Key: PDOQBOJDRPLBQU-QMMMGPOBSA-N InChi: InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1 Smiles: CC1=CC(NC2=NC(N[C@@H](C)C3N=CC(F)=CN=3)=NC=C2Cl)=NN1 Purity: 98.0 Solubility: 10 mM in DMSO Appearance: Solid Power. Shelf Life: 1.0 years
Description	AZD1480 is an orally bioavailable inhibitor of Janus-associated kinase 2 (JAK2) with potential antineoplastic activity. JAK2 inhibitor AZD1480 inhibits JAK2 activation, leading to the inhibition of the JAK/STAT (signal transducer and activator of transcription) signaling including activation of STAT3. This may lead to induction of tumor cell apoptosis and a decrease in cellular proliferation. JAK2, often upregulated or mutated in a variety of cancer cells, mediates STAT3 activation and plays a key role in tumor cell proliferation and survival.