U0126-EtOH

Overview
Catalog #	bs-60422c-2-mg-solid
Product Name	U0126-EtOH
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 426.56 Formula: C20 H22 N6 O S2 CAS Number: 1173097-76-1 InChi Key: CFQULUVMLGZVAF-OYJDLGDISA-N InChi: InChI=1S/C18H16N6S2.C2H6O/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22;1-2-3/h1-8H,21-24H2;3H,2H2,1H3/b17-11+,18-12+; Smiles: CCO.NC1=CC=CC=C1SC(N)=C(C#N)C(C#N)=C(N)SC1=CC=CC=C1N Purity: 98.0 Solubility: DMSO: ≥ 49 mg/mL Appearance: Solid Power Shelf Life: 1.0 years
Description	U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059. This inhibition of MEK1/2 is noncompetitive with ERK and ATP.