SMI-4a

Overview
Catalog #	bs-60416c-2-mg-solid
Product Name	SMI-4a
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 273.23 Formula: C11 H6 F3 N O2 S CAS Number: 438190-29-5 InChi Key: NGJLOFCOEOHFKQ-VMPITWQZSA-N InChi: InChI=1S/C11H6F3NO2S/c12-11(13,14)7-3-1-2-6(4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)/b8-5+ Smiles: O=C1NC(=O)SC1=CC1=CC(=CC=C1)C(F)(F)F Purity: 98.0 Solubility: 10 mM in DMSO Appearance: Solid Power. Shelf Life: 1.0 years
Description	SMI-4a is a potent and selective Pim protein kinase inhibitor, which blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma. SMI-4a was found to induce phosphorylation of extracellular signal-related kinase1/2 (ERK1/2), and the combination of SMI-4a and a mitogen-activated protein kinase kinase 1/2 (MEK1/2) inhibitor was highly synergistic in killing pre-T-LBL cells. SMI-4a may be developed as a therapeutic strategy for the treatment of pre-T-LBL.