RKI-1447

Overview
Catalog #	bs-60415c-2-mg-solid
Product Name	RKI-1447
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 326.37 Formula: C16 H14 N4 O2 S CAS Number: 1342278-01-6 InChi Key: GDVRVPIXWXOKQO-UHFFFAOYSA-N InChi: InChI=1S/C16H14N4O2S/c21-13-3-1-2-11(8-13)9-18-15(22)20-16-19-14(10-23-16)12-4-6-17-7-5-12/h1-8,10,21H,9H2,(H2,18,19,20,22) Smiles: OC1C=C(CNC(=O)NC2=NC(=CS2)C2C=CN=CC=2)C=CC=1 Purity: 98.0 Solubility: 10 mM in DMSO Appearance: Solid Power. Shelf Life: 1.0 years
Description	RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer. RKI-1447 is a Type I kinase inhibitor that binds the ATP binding site through interactions with the hinge region and the DFG motif. RKI-1447 suppressed phosphorylation of the ROCK substrates MLC-2 and MYPT-1 in human cancer cells.