ATB-346

Overview
Catalog #	bs-60414c-2mg-solid
Product Name	ATB-346
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 365.45 Formula: C21 H19 N O3 S CAS Number: 1226895-20-0 InChi Key: YCNMAPLPQYQJFC-UHFFFAOYSA-N InChi: InChI=1S/C21H19NO3S/c1-13(21(23)25-18-8-5-14(6-9-18)20(22)26)15-3-4-17-12-19(24-2)10-7-16(17)11-15/h3-13H,1-2H3,(H2,22,26) Smiles: COC1=CC2C=CC(=CC=2C=C1)C(C)C(=O)OC1C=CC(=CC=1)C(N)=S Purity: 98.0 Solubility: DMSO: ≥ 51.6 mg/mL Appearance: Solid Power Shelf Life: 1.0 years
Description	ATB-346 is anti- inflammatory agent, which is structurally an analogue of naproxen. ABT-346 exhibits anti-inflammatory properties similar to naproxen, but with substantially reduced gastrointestinal toxicity. ATB-346 suppressed colonic prostaglandin synthesis and whole blood thromboxane synthesis as effectively as naproxen, but did not induce any gastrointestinal injury. ATB-346 exerts superior chemopreventive effects to those of naproxen, while sparing the gastrointestinal tract of the injury normally associated with use of the parent drug. ATB-346 may therefore be an attractive agent for chemoprevention of colon cancer, and possibly of cancers in other tissues.