PD-1/PD-L1 Inhibitor C1

Overview
Catalog #	bs-60312c-2-mg-solid
Product Name	PD-1/PD-L1 Inhibitor C1
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 475.58 Formula: C29 H33 N O5 CAS Number: 1675201-83-8 InChi Key: ZBOYJODMIAUJHH-SANMLTNESA-N InChi: InChI=1S/C29H33NO5/c1-20-22(12-9-13-24(20)21-10-5-4-6-11-21)19-35-23-16-27(33-2)25(28(17-23)34-3)18-30-15-8-7-14-26(30)29(31)32/h4-6,9-13,16-17,26H,7-8,14-15,18-19H2,1-3H3,(H,31,32)/t26-/m0/s1 Smiles: CC1C(COC2=CC(OC)=C(CN3CCCC[C@H]3C(O)=O)C(=C2)OC)=CC=CC=1C1C=CC=CC=1 Purity: 98.0 Solubility: DMSO up to 100 mM; Water up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	PD-1/PD-L1 inhibitor C1 is a potent and selective small molecule inhibitor of the PD-1/PD-L1 protein/protein interactions with IC50 < 100 nM (PD-1/PD-L1 Homogenous Time-Resolved Fluorescence (HTRF) binding assay). It may potentially be useful in the treatment of cancer as well as infectious diseases such as hepatitis C. The programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) interaction plays a dominant role in the suppression of T cell responses, especially in a tumor microenvironment, protecting tumor cells from lysis.