BAY11-7082, E2 Ubiquitin Conjugating Enzyme Inhibitor

Overview
Catalog #	bs-60309c-2-mg-solid
Product Name	BAY11-7082, E2 Ubiquitin Conjugating Enzyme Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 207.25 Formula: C10 H9 N O2 S CAS Number: 19542-67-7 InChi Key: DOEWDSDBFRHVAP-KRXBUXKQSA-N InChi: InChI=1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+ Smiles: CC1=CC=C(C=C1)S(=O)(=O)/C=C/C#N Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	BAY11-7082 is a potent and selective E2 ubiquitin (Ub) conjugating enzyme inhibitor. It inhibits the conjugation of Ub to a range of E2 enzymes and inhibits E2 enzyme mediated IκBα phosphorylation and indirectly decreases NF-κb activity. BAY11-7082 also reversibly activates MAPK signaling and induces apoptosis of leukemic T cell and B-cell lymphoma cell lines.