ORY-1001 (RG-6016), LSD1 Inhibitor

Overview
Catalog #	bs-60295c-2-mg-solid
Product Name	ORY-1001 (RG-6016), LSD1 Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 303.27 Formula: C15 H24 Cl2 N2 CAS Number: 1431326-61-2 InChi Key: UCINOBZMLCREGM-RNNUGBGQSA-N InChi: InChI=1S/C15H22N2.2ClH/c16-12-6-8-13(9-7-12)17-15-10-14(15)11-4-2-1-3-5-11;;/h1-5,12-15,17H,6-10,16H2;2*1H/t12?,13?,14-,15+;;/m0../s1 Smiles: Cl.Cl.NC1CCC(CC1)N[C@@H]1C[C@H]1C1C=CC=CC=1 Purity: 98.0 Solubility: DMSO up to 15 mM; Water up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	ORY-1001 is a highly potent and selective inhibitor of Lysine Specific Demethylase 1 (LSD1) with IC50 <20 nM. It is highly selective over related enzymes such as MAO-A/B. ORY-1001 affects AML stem cells, a sub-population of cancer cells that has been proposed to be responsible for frequent relapses of the disease. It significantly reduces tumor cell load and increases survival time in mouse models of Acute Lymphoblastic Leukaemia. Currently ORY-1001 is in Phase I/IIA clinical trial for acute leukemia.