GNF-7, Ras Signaling Inhibitor

Overview
Catalog #	bs-60281c-2-mg-solid
Product Name	GNF-7, Ras Signaling Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 547.53 Formula: C28 H24 F3 N7 O2 CAS Number: 839706-07-9 InChi Key: SZNYUUZOQHNEKB-UHFFFAOYSA-N InChi: InChI=1S/C28H24F3N7O2/c1-16-7-9-21(34-25(39)18-5-4-6-20(11-18)28(29,30)31)12-23(16)38-15-19-13-33-26(36-24(19)37(3)27(38)40)35-22-10-8-17(2)32-14-22/h4-14H,15H2,1-3H3,(H,34,39)(H,33,35,36) Smiles: CN1C2=NC(NC3=CC=C(C)N=C3)=NC=C2CN(C1=O)C1C=C(C=CC=1C)NC(=O)C1C=CC=C(C=1)C(F)(F)F Purity: 98.0 Solubility: DMSO up to 50 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	GNF-7 is a potent, selective and bioavailable Ras signaling inhibitor. It inhibits Ack1 and germinal center kinase (GCK). It can suppress proliferation, and induce cell cycle arrest and apoptosis in leukemia cells harboring NRAS mutations. In vivo GNF-7 showed good efficacy in a xenotransplantation model and activity against primary AML patient samples.