FASCIN-G2, Fascin Inhibitor
| Overview | |
| Catalog # | bs-60269c-2-mg-solid |
| Product Name | FASCIN-G2, Fascin Inhibitor |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Powder: 4C for 1 year. |
| Target | |
| Product Information | Molecular Weight: 385.34 Formula: C20 H14 F3 N3 O2 CAS Number: 1569076-11-4 InChi Key: LWBFIOPAFDTCND-UHFFFAOYSA-N InChi: InChI=1S/C20H14F3N3O2/c21-20(22,23)14-9-7-13(8-10-14)12-26-16-5-2-1-4-15(16)18(25-26)24-19(27)17-6-3-11-28-17/h1-11H,12H2,(H,24,25,27) Smiles: O=C(NC1=NN(CC2C=CC(=CC=2)C(F)(F)F)C2=CC=CC=C21)C1=CC=CO1 Purity: 98.0 Solubility: DMSO up to 50 mM Appearance: Solid Power Shelf Life: 1.0 years |
| Description | FASCIN-G2 is a potent, selective and bioavailable small molecule that inhibits the actin-bundling activity of fascin with Kd ~5-20 µM. It specifically blocks filopodial formation, tumour cell migration and invasion in vitro. , FASCIN-G2 showed very good in vivo efficacy in 4T1 mammary tumour metastasis model and in MDA-MB-231 human breast tumour metastasis model. |
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