SBI-0206965 --- Autophagy Kinase ULK1 Inhibitor

Overview
Catalog #	bs-60268c-2-mg-solid
Product Name	SBI-0206965 --- Autophagy Kinase ULK1 Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 489.32 Formula: C21 H21 Br N4 O5 CAS Number: 1884220-36-3 InChi Key: NEXGBSJERNQRSV-UHFFFAOYSA-N InChi: InChI=1S/C21H21BrN4O5/c1-23-19(27)13-7-5-6-8-15(13)31-20-14(22)11-24-21(26-20)25-12-9-16(28-2)18(30-4)17(10-12)29-3/h5-11H,1-4H3,(H,23,27)(H,24,25,26) Smiles: CNC(=O)C1C=CC=CC=1OC1=NC(NC2C=C(OC)C(OC)=C(C=2)OC)=NC=C1Br Purity: 98.0 Solubility: DMSO up to 50 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	SBI-0206965 is a potent and selective autophagy Kinase ULK1 Inhibitor. Many tumors become addicted to autophagy for survival, suggesting inhibition of autophagy as a potential broadly applicable cancer therapy. SBI-0206965 is a highly selective ULK1 kinase inhibitor in vitro and suppressed ULK1-mediated phosphorylation events in cells, regulating autophagy and cell survival. SBI-0206965 greatly synergized with mechanistic target of rapamycin (mTOR) inhibitors to kill tumor cells, providing a strong rationale for their combined use in the clinic.