Furamidine dihydrochloride --- PRMT1 Inhibitor

Overview
Catalog #	bs-60256c-2mg-solid
Product Name	Furamidine dihydrochloride --- PRMT1 Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 377.27 Formula: C18 H18 Cl2 N4 O CAS Number: 55368-40-6 InChi Key: VXNYQUQHOUERTR-UHFFFAOYSA-N InChi: InChI=1S/C18H16N4O.2ClH/c19-17(20)13-5-1-11(2-6-13)15-9-10-16(23-15)12-3-7-14(8-4-12)18(21)22;;/h1-10H,(H3,19,20)(H3,21,22);2*1H Smiles: Cl.Cl.NC(=N)C1C=CC(=CC=1)C1=CC=C(O1)C1C=CC(=CC=1)C(N)=N Purity: 98.0 Solubility: DMSO and water up to 50 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	Furamidine is a potent, selective and cell permeable Protein arginine methyltransferase-1 (PRMT1) inhibitor with IC50 of 9.4 µM. It has >10-fold selectivity PRMT5, PRMT6 and CARM1 (IC50 are 166, 283 and >400 μM respectively). It targets the enzyme active site and is primarily competitive with the substrate and noncompetitive toward the cofactor. Furamidine effectively inhibits intracellular PRMT1 activity and blocks cell proliferation in leukemia cell lines with different genetic lesions.