A01 --- Smurf1 E3 Ubiquitin Ligase Inhibitor

Overview
Catalog #	bs-60249c-2-mg-solid
Product Name	A01 --- Smurf1 E3 Ubiquitin Ligase Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 512.93 Formula: C22 H20 Cl F3 N4 O3 S CAS Number: 1007647-73-5 InChi Key: QFYLTUDRXBNZFQ-UHFFFAOYSA-N InChi: InChI=1S/C22H20ClF3N4O3S/c1-15-8-9-27-30(15)17-4-2-16(3-5-17)21(31)28-10-12-29(13-11-28)34(32,33)18-6-7-20(23)19(14-18)22(24,25)26/h2-9,14H,10-13H2,1H3 Smiles: CC1=CC=NN1C1C=CC(=CC=1)C(=O)N1CCN(CC1)S(=O)(=O)C1=CC(=C(Cl)C=C1)C(F)(F)F Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	A01 is a potent and selective Smurf1 E3 ubiquitin ligase inhibitor with Kd ~3.7 nM. It attenuates Smurf1-mediated Smad 1/5 degradation and enhances BMP signaling. It also potentiates BMP-2-induced osteoblastic activity in C2C12 myoblasts and MC3T3-E1 osteoblast precursor cells.