Heclin, HECT E3 Ubiquitin Ligase Inhibitor

Overview
Catalog #	bs-60248c-2-mg-solid
Product Name	Heclin, HECT E3 Ubiquitin Ligase Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 283.32 Formula: C17 H17 N O3 CAS Number: 890605-54-6 InChi Key: SPTWXRJNCFIDRQ-ZHACJKMWSA-N InChi: InChI=1S/C17H17NO3/c1-3-15-8-9-16(21-15)10-11-17(20)18-14-6-4-13(5-7-14)12(2)19/h4-11H,3H2,1-2H3,(H,18,20)/b11-10+ Smiles: CC(=O)C1C=CC(=CC=1)NC(=O)C=CC1=CC=C(CC)O1 Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	Heclin is a selective HECT E3 ubiquitin ligase inhibitor, inhibits Nedd4, Smurf2 and WWP1 with IC50 6.3, 6.8 and 6.9 μM respectively. It is selective for HECT-mediated over RING-mediated ubiquitination. Heclin does not block E2 binding but causes a conformational change that results in oxidation of the active site Cys. It kills HEK293 cells growing in culture, consistent with an essential role for HECT ligase activity in mammalian cells.