Verteporfin (Visudyne) --- YAP Inhibitor

Overview
Catalog #	bs-60247c-2-mg-solid
Product Name	Verteporfin (Visudyne) --- YAP Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 718.79 Formula: C41 H42 N4 O8 CAS Number: 129497-78-5 InChi Key: YTZALCGQUPRCGW-MXVXOLGGSA-N InChi: InChI=1S/C41H42N4O8/c1-9-23-20(2)29-17-34-27-13-10-26(39(49)52-7)38(40(50)53-8)41(27,5)35(45-34)19-30-22(4)25(12-15-37(48)51-6)33(44-30)18-32-24(11-14-36(46)47)21(3)28(43-32)16-31(23)42-29/h9-10,13,16-19,38,42,44H,1,11-12,14-15H2,2-8H3,(H,46,47)/b28-16-,29-17-,30-19-,31-16-,32-18-,33-18-,34-17-,35-19-/t38-,41+/m0/s1 Smiles: COC(=O)CCC1=C2C=C3N=C(C=C4NC(=CC5=NC(=CC(N2)=C1C)[C@]1(C)[C@@H](C(=CC=C15)C(=O)OC)C(=O)OC)C(C)=C4C=C)C(C)=C3CCC(O)=O Purity: 98.0 Solubility: DMSO up to 50 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	Verteporfin (Visudyne) is a potent and selective YAP inhibitor, disrupts YAP-TEAD interactions and enhances trypsin cleavage of YAP with EC50 ~100 nM. It inhibits growth and proliferation of retinoblastoma cells. It also significantly blocks cancer stem cell (CSC) properties in cells with high YAP1 and a high proportion of ALDH1(+). In vivo it can suppress YAP-induced liver overgrowth in mice.