TAME hydrochloride --- Ubiquitin Ligase APC/C Inhibitor
| Overview | |
| Catalog # | bs-60246c-2-mg-solid |
| Product Name | TAME hydrochloride --- Ubiquitin Ligase APC/C Inhibitor |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Store in dry, dark place at -20C for 1 year. |
| Target | |
| Product Information | Molecular Weight: 378.87 Formula: C14 H23 Cl N4 O4 S CAS Number: 1784-03-8 InChi Key: JIQFFACVQXXHMY-YDALLXLXSA-N InChi: InChI=1S/C14H22N4O4S.ClH/c1-10-5-7-11(8-6-10)23(20,21)18-12(13(19)22-2)4-3-9-17-14(15)16;/h5-8,12,18H,3-4,9H2,1-2H3,(H4,15,16,17);1H/t12-;/m0./s1 Smiles: Cl.CC1C=CC(=CC=1)S(=O)(=O)N[C@@H](CCCNC(N)=N)C(=O)OC Purity: 98.0 Solubility: DMSO and water up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years |
| Description | TAME is a competitive inhibitor of the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C). It promotes Cdc20 autoubiquitination and inhibits cyclin proteolysis in mitotic Xenopus oocyte extracts (IC50 ~ 12 μM) and blocks cyclin degradation in interphase extract. |
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