PRT4165 --- E3 Ubiquitin-ligase Bmi1/Ring1A Inhibitor

Overview
Catalog #	bs-60245c-2-mg-solid
Product Name	PRT4165 --- E3 Ubiquitin-ligase Bmi1/Ring1A Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 235.24 Formula: C15 H9 N O2 CAS Number: 31083-55-3 InChi Key: OMHZFEWYVFWVLI-UHFFFAOYSA-N InChi: InChI=1S/C15H9NO2/c17-14-11-5-1-2-6-12(11)15(18)13(14)8-10-4-3-7-16-9-10/h1-9H Smiles: O=C1C(=CC2C=NC=CC=2)C(=O)C2=CC=CC=C12 Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	PRT4165 is a small molecule inhibitor of polycomb repressive complex 1, which inhibits ubiquitin signaling at DNA double-strand breaks. PRT4165 is a potent inhibitor of PRC1-mediated H2A ubiquitylation in vivo and in vitro. The drug also inhibits the accumulation of all detectable ubiquitin at sites of DNA double-strand breaks (DSBs), the retention of several DNA damage response proteins in foci that form around DSBs, and the repair of the DSBs.