L755,507, CRISPR Editing Enhancer

Overview
Catalog #	bs-60237c-2-mg-solid
Product Name	L755,507, CRISPR Editing Enhancer
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 584.73 Formula: C30 H40 N4 O6 S CAS Number: 159182-43-1 InChi Key: NYYJKMXNVNFOFQ-MHZLTWQESA-N InChi: InChI=1S/C30H40N4O6S/c1-2-3-4-5-19-32-30(37)33-24-10-16-29(17-11-24)41(38,39)34-25-8-6-23(7-9-25)18-20-31-21-27(36)22-40-28-14-12-26(35)13-15-28/h6-17,27,31,34-36H,2-5,18-22H2,1H3,(H2,32,33,37)/t27-/m0/s1 Smiles: CCCCCCNC(=O)NC1C=CC(=CC=1)S(=O)(=O)NC1C=CC(CCNC[C@H](O)COC2=CC=C(O)C=C2)=CC=1 Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	L-755, 507 was previously characterized as a potent and selective β3 adrenergic receptor partial agonist with EC50 ~0.43 nM. It has > 1000 fold selectivity overβ1- and β2-adrenoceptors (EC50 ~ 580 nM and >10000 nM forβ1- and β2-adrenoceptors respectively). It stimulates lipolysis in rhesus adipocytes in vitro (EC50 = 3.9 nM). In a recent study, L-755, 507 was identified to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types.