CAY10603 --- HDAC6 Inhibitor

Overview
Catalog #	bs-60234c-2-mg-solid
Product Name	CAY10603 --- HDAC6 Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 446.5 Formula: C22 H30 N4 O6 CAS Number: 1045792-66-2 InChi Key: WWGBHDIHIVGYLZ-UHFFFAOYSA-N InChi: InChI=1S/C22H30N4O6/c1-22(2,3)31-21(29)24-16-11-9-15(10-12-16)18-14-17(26-32-18)20(28)23-13-7-5-4-6-8-19(27)25-30/h9-12,14,30H,4-8,13H2,1-3H3,(H,23,28)(H,24,29)(H,25,27) Smiles: CC(C)(C)OC(=O)NC1C=CC(=CC=1)C1=CC(=NO1)C(=O)NCCCCCCC(=O)NO Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	CAY10603 is a potent and selective HDAC6 inhibitor with IC50 of 2 pM. It has 271 nM, 252 nM, 0.42 nM, 6851 nM, and 90.7 nM for HDAC1, 2, 3, 8, and 10, respectively. CAY10603 has potent antiproliferative activity against pancreatic cancer cell lines with IC50 of <1 μM. It could be useful chemical probe to study HDAC biology.