MS436 --- BRD4 Inhibitor

Overview
Catalog #	bs-60232c-2-mg-solid
Product Name	MS436 --- BRD4 Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 383.42 Formula: C18 H17 N5 O3 S CAS Number: 1395084-25-9 InChi Key: DZTGIRNXWSZBIM-QURGRASLSA-N InChi: InChI=1S/C18H17N5O3S/c1-12-10-16(15(19)11-17(12)24)22-21-13-5-7-14(8-6-13)27(25,26)23-18-4-2-3-9-20-18/h2-11,24H,19H2,1H3,(H,20,23)/b22-21+ Smiles: CC1=CC(/N=N/C2C=CC(=CC=2)S(=O)(=O)NC2C=CC=CN=2)=C(N)C=C1O Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	MS436 is a potent and selective BET bromodomain inhibitor with Ki of <0.085 μM and 0.34 μM for BRD4 (1) and BRD4 (2), respectively. It effectively inhibits BRD4 activity in NF-κB-directed production of nitric oxide and proinflammatory cytokine interleukin-6 in murine macrophages without siginificanty inhibition on cell viability. MS436 represents a new class of bromodomain inhibitors to study the functional differences of the two bromodomains of BRD4