RG2833 (RGFP109) --- Brain-penetrant HDAC Inhibitor

Overview
Catalog #	bs-60225c-2-mg-solid
Product Name	RG2833 (RGFP109) --- Brain-penetrant HDAC Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 339.43 Formula: C20 H25 N3 O2 CAS Number: 1215493-56-3 InChi Key: VOPDXHFYDJAYNS-UHFFFAOYSA-N InChi: InChI=1S/C20H25N3O2/c1-15-10-12-16(13-11-15)20(25)22-14-6-2-3-9-19(24)23-18-8-5-4-7-17(18)21/h4-5,7-8,10-13H,2-3,6,9,14,21H2,1H3,(H,22,25)(H,23,24) Smiles: CC1C=CC(=CC=1)C(=O)NCCCCCC(=O)NC1C=CC=CC=1N Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	RG2833 (RGFP109) is a potent and selective brain-penetrant HDAC inhibitor with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3, respectively. It upregulates frataxin mRNA and protein levels dose-dependently in cultures of unstimulated peripheral blood mononuclear cells (PBMC) obtained from FRDA patients. In vivo it corrects frataxin deficiency and increases histone acetylation in the brain and heart of KIKI mice without acute toxicity signs.