BAY 87-2243 --- Hypoxia-inducible Factor-1 (HIF-1) Inhibitor

Overview
Catalog #	bs-60217c-2-mg-solid
Product Name	BAY 87-2243 --- Hypoxia-inducible Factor-1 (HIF-1) Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 525.53 Formula: C26 H26 F3 N7 O2 CAS Number: 1227158-85-1 InChi Key: CDJNNOJINJAXPV-UHFFFAOYSA-N InChi: InChI=1S/C26H26F3N7O2/c1-17-14-22(25-31-24(33-38-25)19-2-6-21(7-3-19)37-26(27,28)29)32-36(17)16-18-8-9-30-23(15-18)35-12-10-34(11-13-35)20-4-5-20/h2-3,6-9,14-15,20H,4-5,10-13,16H2,1H3 Smiles: CC1=CC(=NN1CC1C=CN=C(C=1)N1CCN(CC1)C1CC1)C1=NC(=NO1)C1C=CC(=CC=1)OC(F)(F)F Purity: 98.0 Solubility: DMSO up to 1 mM; EtOH up to 15 mM (heating) Appearance: Solid Power. Shelf Life: 1.0 years
Description	BAY 87-2243 is a highly potent and selective inhibitor of hypoxia-induced gene activation, which has antitumor activities by inhibition of mitochondrial complex I. BAY 87-2243 mproves local tumor control after fractionated irradiation in a schedule-dependent manner in head and neck human xenografts. BAY-87-2243 markedly decreased nuclear HIF-1α expression and pimonidazole hypoxic fraction already after 3 days of drug treatment. BAY-87-2243 prior to RT significantly reduced TCD50 from 123 to 100 Gy (p=0.037). Additional BAY-87-2243 application during RT did not decrease TCD50.