PYZD-4409 --- Ubiquitin-activating Enzyme (E1) Inhibitor

Overview
Catalog #	bs-60213c-2-mg-solid
Product Name	PYZD-4409 --- Ubiquitin-activating Enzyme (E1) Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 351.67 Formula: C14 H7 Cl F N3 O5 CAS Number: 423148-78-1 InChi Key: MSYMKEYWUWVZQY-RMKNXTFCSA-N InChi: InChI=1S/C14H7ClFN3O5/c15-10-5-7(1-3-11(10)16)18-14(21)9(13(20)17-18)6-8-2-4-12(24-8)19(22)23/h1-6H,(H,17,20)/b9-6+ Smiles: [O-][N+](=O)C1=CC=C(C=C2C(=O)NN(C3=CC(Cl)=C(F)C=C3)C2=O)O1 Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	PYZD-4409 is a novel potent, selective and cell permeable inhibitor of ubiquitin-activating enzyme (E1). It induces cell death in hematologic malignant cell lines and primary patient samples preferentially over normal hematopoietic cells. PYZD-4409 blocks degradation of the short-lived proteins p53 and cyclin D3. It inhibits NF-κB activation and induces cell death associated with ER stress. It also displays antitumor effects in a mouse model of leukemia by intraperitoneal administration of the drug.