UNC0646 --- G9a/GLP HMTase Inhibitor

Overview
Catalog #	bs-60184c-2-mg-solid
Product Name	UNC0646 --- G9a/GLP HMTase Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 621.9 Formula: C36 H59 N7 O2 CAS Number: 1320288-17-2 InChi Key: OUKWLRHRXOPODD-UHFFFAOYSA-N InChi: InChI=1S/C36H59N7O2/c1-28(2)41-19-10-20-43(24-23-41)36-38-32-27-34(45-25-11-18-40-16-8-5-9-17-40)33(44-3)26-31(32)35(39-36)37-29-14-21-42(22-15-29)30-12-6-4-7-13-30/h26-30H,4-25H2,1-3H3,(H,37,38,39) Smiles: CC(C)N1CCN(CCC1)C1=NC2=CC(OCCCN3CCCCC3)=C(C=C2C(NC2CCN(CC2)C2CCCCC2)=N1)OC Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	UNC0646 is a novel potent, selective and cell permeable inhibitor of the homologous protein lysine methyltransferases, G9a and GLP, with IC50 ~6 nM and 15 nM for G9a and GLP, respectively. It potently inhibits G9a/GLP methyltransferase activity in cells (IC50 ~10 nM in MCF7 cells), and exhibits low toxicity. It is highly selective for G9a/GLP over several other protein lysine and arginine methyltransferases. UNC0646 did not affect G9a co-activator function but selectively decreased G9a co-repressor function for endogenous target genes.