ML324 --- JMJD2 Histone Demethylase Inhibitor

Overview
Catalog #	bs-60183c-2mg-solid
Product Name	ML324 --- JMJD2 Histone Demethylase Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 349.43 Formula: C21 H23 N3 O2 CAS Number: 1222800-79-4 InChi Key: QDBVSOZTVKXUES-UHFFFAOYSA-N InChi: InChI=1S/C21H23N3O2/c1-24(2)12-4-11-23-21(26)16-8-6-15(7-9-16)18-13-17-5-3-10-22-20(17)19(25)14-18/h3,5-10,13-14,25H,4,11-12H2,1-2H3,(H,23,26) Smiles: CN(C)CCCNC(=O)C1C=CC(=CC=1)C1=CC(O)=C2N=CC=CC2=C1 Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	ML324 is a potent, selective and cell permeable inhibitor of Jumonji domain-containing protein 2 (JMJD2) histone demethylase with IC50 ~0.92 µM toward JMJD2E. It has excellent in vitro ADME properties, and it could effectively block both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection via inhibition viral IE gene expression. ML324 suppresses the formation of HSV plaques, even at high MOI, and blocks HSV-1 reactivation in a mouse ganglia explant model of latently infected mice.