Bromosporine --- Pan-bromodomain Inhibitor
| Overview | |
| Catalog # | bs-60144c-2-mg-in-solid |
| Product Name | Bromosporine --- Pan-bromodomain Inhibitor |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Store in dry, dark place at -20C for 1 year. |
| Target | |
| Product Information | Molecular Weight: 404.44 Formula: C17 H20 N6 O4 S CAS Number: 1619994-69-2 InChi Key: UYBRROMMFMPJAN-UHFFFAOYSA-N InChi: InChI=1S/C17H20N6O4S/c1-5-27-17(24)18-15-9-14(21-23-11(3)19-20-16(15)23)12-7-6-10(2)13(8-12)22-28(4,25)26/h6-9,22H,5H2,1-4H3,(H,18,24) Smiles: CC1=NN=C2C(=CC(=NN12)C1C=CC(C)=C(C=1)NS(C)(=O)=O)NC(=O)OCC Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years |
| Description | Bromosporine is a broad spectrum inhibitor for bromodomains with IC50 of 0.41 μM, 0.29 μM, 0.122 μM and 0.017 μM for BRD2, BRD4, BRD9 and CECR2, respectively. In cell-based assays, Bromosporine (1 µM) accelerates FRAP recovery of BRD4 and CREBBP, while shows no activities against TIF1α, BAZ2A, and SMARCA2 (at 10 µM). Bromosporine shows moderate cytotoxicity in HeLa cells at 18 µM. It is a very useful chemical probe for bromodomain functional assays. |
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