EX-527 --- SIRT1 Inhibitor
| Overview | |
| Catalog # | bs-60108c-2mg-solid |
| Product Name | EX-527 --- SIRT1 Inhibitor |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Store in dry, dark place at -20C for 1 year. |
| Target | |
| Product Information | Molecular Weight: 248.71 Formula: C13 H13 Cl N2 O CAS Number: 49843-98-3 InChi Key: FUZYTVDVLBBXDL-UHFFFAOYSA-N InChi: InChI=1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)8-2-1-3-9(13(15)17)12(8)16-11/h4-6,9,16H,1-3H2,(H2,15,17) Smiles: NC(=O)C1CCCC2C3=CC(Cl)=CC=C3NC=21 Purity: 98.0 Solubility: DMSO up to 50 mM Appearance: Solid Power. Shelf Life: 1.0 years |
| Description | EX-527 is a highly potent and selective inhibitor of SIRT1 with an IC50 ~98 nM. It does not inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members (IC50 ~20-100 µM). EX-527 has been used to investigate the relationship between SIRT1-mediated deacetylation of p53, p53 activity, and cell survival following DNA damage, as well as many other biological processes involving SIRT1. |
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