Kartogenin (KGN) --- Chondrogenesis Modulator
| Overview | |
| Catalog # | bs-60027c-2mg-solid |
| Product Name | Kartogenin (KGN) --- Chondrogenesis Modulator |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Store in dry, dark place at -20C for 1 year. |
| Target | |
| Product Information | Molecular Weight: 317.34 Formula: C20 H15 N O3 CAS Number: 4727-31-5 InChi Key: SLUINPGXGFUMLL-UHFFFAOYSA-N InChi: InChI=1S/C20H15NO3/c22-19(17-8-4-5-9-18(17)20(23)24)21-16-12-10-15(11-13-16)14-6-2-1-3-7-14/h1-13H,(H,21,22)(H,23,24) Smiles: OC(=O)C1C=CC=CC=1C(=O)NC1C=CC(=CC=1)C1C=CC=CC=1 Purity: 98.0 Solubility: DMSO up to 50 mM Appearance: Solid Power. Shelf Life: 1.0 years |
| Description | Kartogenin (KGN) is a potent small molecule that can promote chondrocyte differentiation of human mesenchymal stem cells/MSCs (EC50 = 100 nM). It was identified by an imaging-based high throughput screening in human MSCs. KGN also shows chondro-protective effects in vitro, and is efficacious in collagenase and surgery induced OA models in mice. MOA studies suggested that KGN binds to filamin A, disrupts its interaction with the transcription factor CBFβ, and induces chondrogenesis by regulating the CBFβ-RUNX1 transcriptional program. Kartogenin serves as a very useful tool to study and promote chondrogenesis, and may provide a new strategy of cell-based therapy for treating osteoarthritis. |
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