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PLC gamma 1 (Tyr783) Polyclonal Antibody, PE Conjugated

Applications

  • WB
  • FCM

Reactivity

  • Mouse
  • Rat

Predicted Reactivity

  • Human
  • Dog
  • Pig
  • Horse
  • Chicken
Overview
Catalog # bs-3343R-PE
Product Name PLC gamma 1 (Tyr783) Polyclonal Antibody, PE Conjugated
Applications WB, FCM
Specificity This phosphorylation site is homologous across the listed species.
Reactivity Mouse, Rat
Predicted Reactivity Human, Dog, Pig, Horse, Chicken
Specifications
Conjugation PE
Host Rabbit
Source KLH conjugated synthetic phosphopeptide derived from human PLC gamma 1 around the phosphorylation site of Tyr783
Modification Site Tyr783
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Target
Gene ID 5335
Swiss Prot P19174
Subcellular location Cytoplasm, Nucleus
Synonyms PLC1; NCKAP3; PLC-II; PLC148; PLCgamma1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; PLC-148; Phosphoinositide phospholipase C-gamma-1; Phospholipase C-II; Phospholipase C-gamma-1; PLC-gamma-1; PLCG1
Background Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.
Application Dilution
WB 1:300-5000
FCM 1:20-100