PAWR Polyclonal Antibody

Applications

WB
ELISA

Reactivity

Human
Mouse
Rat

Predicted Reactivity

Cow
Rabbit

Overview
Catalog #	bs-25044R
Product Name	PAWR Polyclonal Antibody
Applications	WB, ELISA
Reactivity	Human, Mouse, Rat
Predicted Reactivity	Cow, Rabbit
Specifications
Conjugation	Unconjugated
Host	Rabbit
Source	KLH conjugated synthetic peptide derived from human PAWR
Immunogen Range	101-200/340
Clonality	Polyclonal
Isotype	IgG
Concentration	1ug/ul
Purification	Purified by Protein A.
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage Condition	Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Target
Gene ID	Q96IZ0
Swiss Prot	5074
Subcellular location	Cytoplasm, Nucleus
Synonyms	2310001G03Rik ; PAR 4 ; PAR-4 ; Pawr ; PAWR_HUMAN ; PRKC Apoptosis WT1 Regulator ; PRKC apoptosis WT1 regulator protein ; Prostate apoptosis response 4 protein ; Prostate apoptosis response protein 4 ; prostate apoptosis response protein PAR-4 ; Transcriptional repressor Par-4-like protein PAWR ; Transcriptional repressor PAR4 ; WT1 Interacting Protein
Background	Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.
Application Dilution
WB	1:300-5000
ELISA	1:500-1000