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HMGB1 Polyclonal Antibody, HRP Conjugated

Applications

  • IHC-P

Reactivity

  • Human
Overview
Catalog # bs-24465R-HRP
Product Name HMGB1 Polyclonal Antibody, HRP Conjugated
Applications IHC-P
Reactivity Human
Specifications
Conjugation HRP
Host Rabbit
Source KLH conjugated synthetic peptide derived from human HMGB1:121-215/215
Immunogen Range 121-215/215
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Target
Gene ID 3146
Swiss Prot P09429
Subcellular location Cytoplasm, Nucleus, Secreted, Cell membrane, Endosome, ER-Golgi intermediate compartment membrane
Synonyms Amphoterin; High mobility group 1; High Mobility Group Box 1; High mobility group protein 1; High mobility group protein B1; HMG3; HMGB 1;HMGB-1; Hmgb1 protein; Nonhistone chromosomal protein HMG1; SBP 1; SBP-1; Sulfoglucuronyl carbohydrate binding protein; HMGB1_HUMAN.
Background High Mobility Group Box-1 (HMGB1) is a cytokine implicated in the pathogenesis of rheumatoid arthritis (RA) and other inflammatory diseases. The cholinergic anti-inflammatory pathway, a vagus nerve dependent mechanism, inhibits HMGB1 release in experimental disease models Function : DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells. Subunit : Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2. Subcellular Location : Nucleus. Chromosome.
Application Dilution
IHC-P 1:200-400