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Dnmt3b Polyclonal Antibody, Cy7 Conjugated

Applications

  • WB
  • FCM

Reactivity

  • Human
  • Mouse

Predicted Reactivity

  • Dog
  • Horse
  • Rabbit
Overview
Catalog # bs-20680R-Cy7
Product Name Dnmt3b Polyclonal Antibody, Cy7 Conjugated
Applications WB, FCM
Reactivity Human, Mouse
Predicted Reactivity Dog, Horse, Rabbit
Specifications
Conjugation Cy7
Host Rabbit
Source KLH conjugated synthetic peptide derived from human Dnmt3b
Immunogen Range 251-350/853
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Target
Gene ID 1789
Swiss Prot Q9UBC3
Subcellular location Nucleus
Synonyms DNA (cytosine-5)-methyltransferase 3B; DNMT3B; DNA methyltransferase HsaIIIB; DNA MTase HsaIIIB; M.HsaIIIB
Background Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells (PubMed:27153398).
Application Dilution
WB 1:300-5000
FCM 1:20-100