Overview |
bs-14241R |
DEF8 Polyclonal Antibody |
WB, IHC-P, IHC-F, IF(ICC), IF |
Human, Mouse, Rat |
Specifications |
Unconjugated |
Rabbit |
KLH conjugated synthetic peptide derived from human DEF8 |
151-250/512 |
Polyclonal |
IgG |
1ug/ul |
Purified by Protein A. |
Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. |
Store at -20°C for 12 months. |
Target |
54849 |
Q6ZN54 |
DEF-8; Def8; Def 8; DEFI8_HUMAN; Differentially expressed in FDCP 8 homolog; FLJ20186; MGC104349. |
DEF8 is a 512 amino acid protein that is expressed at highest levels in peripheral leukocytes. It is expressed as five isoforms as a result of alternative splicing events. The gene encoding DEF8 maps to chromosome 16, which encodes over 900 genes in approximately 90 million base pairs, makes up nearly 3% of human cellular DNA and is associated with a variety of genetic disorders. The rare disorder Rubinstein-Taybi syndrome is associated with chromosome 16, as is Crohn's disease, a gastrointestinal inflammatory condition that may involve the NOD2 gene. An association with systemic lupus erythematosis and a number of other autoimmune disorders with the pericentromeric region of chromosome 16 has led to the identification of SLC5A11 as a potential autoimmune modifier. |
Application Dilution |
WB |
|
IHC-P |
1:200-400 |
IHC-F |
1:100-500 |
IF(ICC) |
1:50-200 |
IF |
|