| Overview |
| bs-13240R-PE |
| FZR1/CDC20C Polyclonal Antibody, PE Conjugated |
| WB |
| Human, Mouse |
| Rat, Dog, Cow, Sheep, Pig, Horse, Chicken |
| Specifications |
| PE |
| Rabbit |
| KLH conjugated synthetic peptide derived from human FZR1/CDC20C |
| 141-240/496 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 51343 |
| Q9UM11 |
| Cytoplasm, Nucleus |
| FZR; FZR2; CDC20C; Fizzy-related protein homolog; CDC20-like protein 1; Cdh1/Hct1 homolog; FZR1; FYR; KIAA1242 |
| Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. |
| Application Dilution |
| WB |
1:300-5000 |
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