| Overview |
| bs-12935R-PE |
| CSTF3/CSTF77 Polyclonal Antibody, PE Conjugated |
| WB |
| Mouse |
| Human, Rat, Dog, Cow, Chicken, Rabbit |
| Specifications |
| PE |
| Rabbit |
| KLH conjugated synthetic peptide derived from human CSTF3/CSTF77 |
| 151-250/717 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 1479 |
| Nucleus |
| CF 1 77 kDa subunit; Cleavage stimulation factor 77 kDa subunit; Cleavage stimulation factor subunit 3; Cleavage stimulation factor subunit 3 isoform 1; CSTF 3; CSTF 77; CSTF 77 kDa subunit; CSTF77; MGC117398; MGC43001; MGC75122; CSTF3_HUMAN. |
| Polyadenylation of mRNA precursors is a two-step reaction that requires multiple protein factors. The first step, endonucleolytic cleavage of polyadenylation substrates, requires CstF (cleavage stimulation factor), a heterotrimer that is composed of three distinct subunits. Heterotrimeric CstF recognizes GU- and U-rich sequences located downstream of the polyadenylation site on RNA. CstF-77 (cleavage stimulation factor, 77 kDa subunit), also known as CstF3, is one of the three subunits comprising CstF. It can exist as a homodimer and functions as the bridge, directly interacting with the other two CstF subunits, namely CstF-64 and CstF-50. CstF-77 is highly conserved among eukaryotes. It contains an Alpha-helical structure with 11 HAT (Half-a-TPR-containing) repeats and is essential for CstF assembly. In addition, CstF-77 is capable of interacting with CPSF1 and FCP1, other factors involved in polyadenylation. |
| Application Dilution |
| WB |
1:300-5000 |
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