| Overview |
| bs-12689R-PE |
| PKC iota Polyclonal Antibody, PE Conjugated |
| WB |
| Human, Mouse |
| Rat, Cow, Sheep, Pig, Horse |
| Specifications |
| PE |
| Rabbit |
| KLH conjugated synthetic peptide derived from human PKC iota/PKCI |
| 181-280/596 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 5584 |
| P41743 |
| Cytoplasm, Nucleus, Cell membrane |
| aPKC lambda/iota; aPKC-lambda/iota; Atypical protein kinase C lambda/iota; Atypical protein kinase C-lambda/iota; DXS1179E; KPCI_HUMAN; MGC26534; nPKC iota; nPKC-iota; nPKCiota; PKC lambda; PKCI; PKCiota; PKClambda; PRKC iota; PRKC lambda/iota; PRKC-lambda/iota; PRKCI; Protein kinase C iota; Protein kinase C iota type. |
| This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008] |
| Application Dilution |
| WB |
1:300-5000 |
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