S1RA hydrochloride

Overview
Catalog #	bs-1080c-2mg-solid
Product Name	S1RA hydrochloride
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 373.88 Formula: C20 H24 Cl N3 O2 CAS Number: 1265917-14-3 InChi Key: SHRYQZBTQDMGLZ-UHFFFAOYSA-N InChi: InChI=1S/C20H23N3O2.ClH/c1-16-14-20(25-13-10-22-8-11-24-12-9-22)21-23(16)19-7-6-17-4-2-3-5-18(17)15-19;/h2-7,14-15H,8-13H2,1H3;1H Smiles: Cl.CC1=CC(=NN1C1=CC2=CC=CC=C2C=C1)OCCN1CCOCC1 Purity: 98.0 Solubility: DMSO: ‚â• 57 mg/mL Appearance: Solid Power Shelf Life: 1.0 years
Description	E-52862, also known as S1RA and MR390, is a selective sigma-1 receptor antagonist, with a reported binding affinity of Ki = 17.0 ¬± 7.0 nM, selective over the sigma-2 receptor and against a panel of other 170 receptors, enzymes, transporters and ion channels. In preclinical studies, S1RA has demonstrated efficacy in relieving neuropathic pain and pain in other sensitizing conditions, associated with an improvement of the emotional negative state. E-52862 attenuates neuropathic pain of different aetiology in rats.