GNF-2

Overview
Catalog #	bs-1020c-2mg-solid
Product Name	GNF-2
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 374.32 Formula: C18 H13 F3 N4 O2 CAS Number: 778270-11-4 InChi Key: WEVYNIUIFUYDGI-UHFFFAOYSA-N InChi: InChI=1S/C18H13F3N4O2/c19-18(20,21)27-14-6-4-13(5-7-14)25-16-9-15(23-10-24-16)11-2-1-3-12(8-11)17(22)26/h1-10H,(H2,22,26)(H,23,24,25) Smiles: NC(=O)C1C=C(C=CC=1)C1=CC(NC2C=CC(=CC=2)OC(F)(F)F)=NC=N1 Purity: 98.0 Solubility: DMSO: ‚â• 45 mg/mL Appearance: Solid Power Shelf Life: 1.0 years
Description	GNF-2 is an allosteric inhibitor of Bcr-abl tyrosine kinase activity (IC50 = 267 nM); inhibits proliferation and induces apoptosis in Bcr-abl-expressing cells. Selective for Bcr-abl over a panel of serine, threonine and tyrosine kinases. Non-ATP-competitive.