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BCL-2 (2C4) Monoclonal Antibody

Applications

  • WB
  • IHC-P
  • IF(ICC)

Reactivity

  • Human
  • Mouse
Overview
Catalog # bsm-52022M
Product Name BCL-2 (2C4) Monoclonal Antibody
Applications WB, IHC-P, IF(ICC)
Reactivity Human, Mouse
Specifications
Conjugation Unconjugated
Host Mouse
Source Recombinant human BCL-2 protein, around 50-150aa.
Clonality Monoclonal
Clone # 2C4
Isotype IgG2b
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide.
Storage Condition Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Target
Gene ID 596
Swiss Prot P10415
Synonyms Apoptosis regulator Bcl-2; BCL2
Background Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).
Application Dilution
WB 1:300-5000
IHC-P 1:200-400
IF(ICC) 1:50-200