Overview |
bsm-60278R |
IKZF1 monoclonal Antibody |
WB, IHC-P, IF, ICC |
Human |
Specifications |
Unconjugated |
Rabbit |
KLH conjugated synthetic peptide derived from human IKZF1 |
Monoclonal |
IK3C9 |
IgG |
1mg/ml |
Purified by Protein A. |
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
Target |
10320 |
Q13422 |
Cytoplasm, Nucleus |
IKAROS family zinc finger 1 (Ikaros); PRO0758; CLL associated antigen KW 6; DNA-binding protein Ikaros; hIk 1; hIk-1; IK1; Ikaros (zinc finger protein); IKAROS; Ikaros family zinc finger protein 1; IKZF1_HUMAN; LYF1; Lymphoid transcription factor LyF-1; zinc finger protein subfamily 1A 1; ZNFN1A1. |
This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014] |
Application Dilution |
WB |
=1:500-2000 |
IHC-P |
IHC-P=1:200-500 |
IF |
ICC=1:50 |
ICC |
IF=1:50-100 |