GNB2 Monoclonal Antibody
Applications
Reactivity
Overview | |
Catalog # | bsm-54648R |
Product Name | GNB2 Monoclonal Antibody |
Applications | WB, FCM, IHC-P, IHC |
Reactivity | Human, Mouse, Rat |
Specifications | |
Conjugation | Unconjugated |
Host | Rabbit |
Source | Synthetic Peptide within N terminal human GNB2. |
Clonality | Monoclonal |
Clone # | 8D3 |
Isotype | IgG |
Concentration | 1ug/ul |
Purification | Purified by Protein A. |
Storage Buffer | Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide. |
Storage Condition | Store at -20°C for 12 months. |
Target | |
Gene ID | 2782 |
Swiss Prot | P62879 |
Subcellular location | Perinuclear region |
Synonyms | G protein beta 2 subunit antibody, G protein subunit beta 2 antibody, G protein subunit beta-2 antibody, GBB2_HUMAN antibody, Gnb2 antibody, Gnb2l1 antibody, Guanine nucleotide binding protein beta 2 subunit antibody, Guanine nucleotide binding protein G I G S G T beta 2 subunit 2 antibody, Guanine nucleotide binding protein G protein beta polypeptide 2 antibody, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 antibody, OTTHUMP00000174601 antibody, OTTHUMP00000174602 antibody, RACK1 antibody, Receptor for activated C kinase antibody, Receptor of activated protein kinase C 1 antibody, Signal transducing guanine nucleotide binding regulatory protein beta antibody, Transducin beta chain 2 antibody |
Background | G protein beta subunit GI/GS/GT (guanine nucleotide-binding protein G). WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment. |
Application Dilution | |
WB | 1:300-5000 |
FCM | 1:20-100 |
IHC-P | 1:200-400 |
IHC |