Overview |
bsm-52314R |
Caspase-9 (2A7) Monoclonal Antibody |
WB, IHC-P, IF(IHC-P), IF(ICC) |
Human, Mouse |
Specifications |
Unconjugated |
Rabbit |
Recombinant human Caspase-9 between 200 to 350 amino acids |
Monoclonal |
2A7 |
IgG |
1ug/ul |
Purified by Protein A. |
Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide. |
Store at -20°C for 12 months. |
Target |
842 |
P55211 |
Mitochondrion |
Caspase-9; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; ICE-like apoptotic protease 6; CASP-9; APAF-3; ICE-LAP6; CASP9 |
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9. |
Application Dilution |
WB |
1:300-5000 |
IHC-P |
1:200-400 |
IF(IHC-P) |
1:50-200 |
IF(ICC) |
1:50-200 |