Overview |
bsm-52265R |
Integrin alpha-6 (4F7) Monoclonal Antibody |
WB, IHC-P |
Human, Mouse, Rat |
Specifications |
Unconjugated |
Rabbit |
Recombinant Human Integrin alpha 6 between 1 to 100 amino acids |
1-100/1130 |
Monoclonal |
4F7 |
IgG |
1ug/ul |
Purified by Protein A. |
Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide. |
Store at -20°C for 12 months. |
Target |
3655 |
P23229 |
Cell membrane |
Integrin alpha-6; CD49 antigen-like family member F; VLA-6; CD49f; ITGA6 |
Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling. |
Application Dilution |
WB |
1:300-5000 |
IHC-P |
1:200-400 |