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CD276 Monoclonal Antibody

Applications

  • WB
  • IHC-P

Predicted Reactivity

  • Human
Overview
Catalog # bsm-51711M
Product Name CD276 Monoclonal Antibody
Applications WB, IHC-P
Predicted Reactivity Human
Specifications
Conjugation Unconjugated
Host Mouse
Source Recombinant human CD276.
Clonality Monoclonal
Clone # F6D12
Concentration 0.5ug/ul
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage Condition Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Target
Gene ID 80381
Swiss Prot Q5ZPR3
Subcellular location Cell membrane
Synonyms B7H3; 4Ig B7 H3; 4Ig-B7-H3; AU016588; B7 H3; B7 homolog 3; B7-H3; B7H3; B7RP-2; CD_antigen=CD276; CD276; CD276 antigen; CD276 molecule; CD276_HUMAN; Costimulatory molecule; PSEC0249; UNQ309/PRO352.
Background May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.
Application Dilution
WB =1:1000-2000,IHC-P=1:100-400,IHC-F=1:100-400,
IHC-P 1:200-400